DOT HS 809 714

TABLE OF CONTENTS

1.1 Statement of The Problem

1.2 Limitations of Epidemiological Data

1.3 Clinical Pharmacology & Issue of Drug Choice

1.4 Prior Reviews of H ₁ -antagonists

1.5 Focus of Current Review

2. METHOD

Reasons for Study Exclusion (Table 1)

The Ten Drugs Selected for Review (Table 2)

Number of Studies and Test Findings for each Skill Category and Subjective Sedation:
Acute and Repeated Dosing (Table 3)

3. RESULTS

3.1. Overall Impairment

3.2. Impairment by Individual Drugs as a Function of Acute Dose Level

3.3. Acute Dose Impairment by Behavioral Categories

3.3. 1. DRIVING AND PILOTING

3.3. 2. PSYCHOMOTOR SKILLS

3.3. 3. PERCEPTION

3.3. 4. VISUAL FUNCTIONS & CRITICAL FLICKER FUSION

3.3. 5. COGNITIVE TASKS

3.3. 6. DIVIDED ATTENTION

3.3. 7. VIGILANCE TASKS

3.3. 8. TRACKING

3.3. 9. REACTION TIME

3.3. 10. PHYSIOLOGICAL MEASURES OF SEDATION

4. SUMMARY AND DISCUSSION

5. CONCLUSIONS

REFERENCE LIST A
Articles Referenced in Report

REFERENCE LIST B
Articles Included in the Review

FIGURES

APPENDICES (PDF Format)

Appendix A - Tables of Impairment Findings by Behavioral Category (Tables 4-15)

Appendix B - Example of an Impairment Summary Sheet (YES/NO) by Behavioral Category

Appendix C - Example of a Study Summary Sheet (n=138 studies from 130 references)

Appendix D - Summary Table of Impairment Findings by Study (includes all 10 Drugs)

LIST OF TABLES

1. Reasons for Study Exclusion

2. The Ten Drugs Selected for Review

3. Number of Studies and Test Findings for each Skill Category and Subjective Sedation

4-14. Summary of Test Results by Behavioral Category (Appendix A)

Table 4. SUBJECTIVE MEASURES OF SEDATION

Table 5. DRIVING AND PILOTING

Table 6. PSYCHOMOTOR SKILLS

Table 7. PERCEPTION

Table 8. VISUAL FUNCTIONS & CRITICAL FLICKER FUSION

Table 9. COGNITIVE TASKS

Table 10. DIVIDED ATTENTION

Table 11. VIGILANCE TASKS

Table 12. TRACKING

Table 13. REACTION TIME

Table 14. PHYSIOLOGICAL MEASURES OF SEDATION